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SwitchGear Genomics unveils LightSwitch Luciferase Assay System

SwitchGear Genomics, a provider of products for studying the regulatory elements in the human genome, has unveiled LightSwitch Luciferase Assay System, a comprehensive reporter assay solution for measuring transcriptional activation and translational efficiency in living cells.

The new SwitchGear LightSwitch system includes a genome-wide collection of assay-ready GoClone promoter and 3’UTR luciferase reporters paired with optimized LightSwitch luciferase assay reagents.

The GoClone reporter vectors utilize a novel luciferase gene and a luciferase reagent developed by SwitchGear to provide sensitivity.

The complete reporter assay solution enables researchers to rapidly measure the promoter and 3’UTR activity for any gene in the genome.

SwitchGear Genomics co-founder and CEO Nathan Trinklein said SwitchGear has created an optimized luminescent reporter RenSP by increasing the gene’s overall light output and decreasing the half-life of the reporter protein.

"We functionally screened thousands of synthetic gene sequence variants with predicted improvements and removed sequence elements that might interfere with expression measurements," Trinklein said.

"The result is a luciferase that is nearly 100% brighter than other luminescent reporter genes and that has been optimized for use with our companion reagents."