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Sigma Life Science introduces Targeted Integration Kit

Sigma Life Science, a biological products and services research business of Sigma-Aldrich, has introduced CompoZr Targeted Integration Kit - mRosa26 to integrate transgenes into the mouse genome at the Rosa26 safe harbor locus.

Sigma’s CompoZr Targeted Integration Kits use zinc finger nucleases (ZFNs) for heritable gene knockin at the target locus (Rosa26 or AAVS1).

Sigma Life Science also introduced CompoZr Targeted Integration Kit – AAVS1, for transgene integration in the human genome.

The company said both Human and Mouse kits are supplied with the ZFNs and donor plasmid to perform transgene integration by ZFN-assisted homologous recombination, reducing the timescale and complexity of engineering transgenic mouse and human cell lines.

Sigma Life Science Functional Genomics Global Commercial Marketing manager Supriya Shivakumar said this latest release is part of Sigma’s ongoing objective to increase the research community’s access to advanced genomic engineering strategies by offering products based on their proprietary zinc finger nuclease technology.