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Researchers Show High Risk Of Asthma Associated With Depression

According to the study, children with asthma are at double the risk of having depression compared to those without asthma. This may lead to death in some cases.

Researchers from the University at Buffalo found that depressed children with asthma exhibit a dysregulation of the autonomic nervous system along with increased airway compromise.

This is supposed to be the first study to examine pathways linking emotional stress, depressive symptoms, autonomic nervous system dysregulation and airway function in childhood asthma.

Bruce D. Miller, M.D., and Beatrice L. Wood, Ph.D., professors of psychiatry and pediatrics in the UB School of Medicine and Biomedical Sciences, designed and conducted the study in collaboration with other UB researchers.

The autonomic nervous system, or ANS, is composed of two opposing divisions, the sympathetic and parasympathetic nerves, which check one another and thus control critical body functions outside of conscious awareness, explained Miller, chief of the UB Division of Child & Adolescent Psychiatry and senior staff psychiatrist at Women & Children’s Hospital of Buffalo, a UB-affiliated teaching hospital. The ANS is influenced by stress and emotions.

Children with asthma and high depression symptoms showed a preponderance of parasympathetic over sympathetic nervous system reactivity in the ANS, he continued. This imbalance within the ANS could explain the increased airway resistance that we found in depressed asthmatic children in our study.

The study in which 90 children with age 7-17 were involved, 45 asthmatic children with symptoms of depression were compared with 45 asthmatic children without symptoms of depression. Both groups viewed scary, sad (death) and happy scenes from the movie, The Extraterrestrial.

Electrodes worn collected data on heart and respiratory function, which showed the level of activation and reactivity of the sympathetic and parasympathetic divisions. Airway function was assessed before the movie, after the death scene and after the movie.

The depressed group consistently showed greater parasympathetic activation along with decreased sympathetic activation in response to the emotional provocations – a pattern that would have a detrimental effect on the airways, said Miller.

In contrast, the group without symptoms of depression showed consistent activation of the sympathetic pathway, which would support better airway function under stress. To our knowledge, this is the first report in the literature to demonstrate an association linking stress, depression and increased airway resistance in asthmatic children.

in addition, results showed that bias toward parasympathetic reactivity was most pronounced in the children during scenes portraying family distress or loss, death and dying.

These findings reinforce previous results from our laboratory that associated relational stress within the family with child depression and increased asthma activity, said Wood.

Although these findings are promising and support our hypotheses, she continued, we need further studies to replicate and extend these findings, and to examine whether treatment for depression reduces shift to the parasympathetic and improves lung function in children with asthma.

The authors suggested these findings indicate the importance of screening children with asthma for depressive symptoms, of following these children closely and referring them for psychosocial counseling when indicated.