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Nasal Provocation Test Helps In Diagnosis Of Latex Allergy

According to a report, the nasal provocation test is more sensitive than the glove test for diagnosing natural rubber latex allergy.

Dr. Mehmet Unsel and researchers from Ege University Medical Faculty, Izmir, Turkey reported that a standard nasal provocation method has yet to be established.

The nasal provocation test showed positive results in 84.6% and negative in 15.4% of patients with positive skin prick test to natural rubber latex, compared with 50% positive and 50% negative glove responses.

The results of nasal provocation test were negative in patients with positive skin prick tests to other inhaler allergens and in a control group with no allergic diseases.

The investigators reported that using skin prick test positivity to natural rubber latex and a history of natural rubber latex-associated rhinitis for diagnosing natural rubber latex allergy, nasal provocation test had a sensitivity of 96%, specificity of 100%, negative predictive value of 98%, and positive predicative value of 100%.

After comparing the reusults, the glove use test had 81% sensitivity, 90% specificity, negative predictive value of 75%, and positive predictive value of 93%.

Nasal provocation test was successfully used for the first time in the diagnosis of natural rubber latex allergy, the authors conclude